A Free Syrian Army fighter takes position behind sandbags in the old city of Aleppo, Syria, on Tuesday, August 27. Syria has warned Western leaders against taking any military action after international outrage over the country's suspected use of chemical weapons. Tensions in Syria began to flare in March 2011 and have escalated into an ongoing civil war. Click through to view the most compelling images taken since the start of the conflict. 
A U.N. team leaves its Damascus, Syria, hotel in a convoy on Monday, August 26. The team was to investigate an alleged chemical attack that killed hundreds last week in a suburb of the Syrian capital. Sniper fire hit a vehicle used by the U.N. chemical weapons investigation team multiple times Monday, according to the United Nations. 
A Syrian soldier walks down a street in Damascus on Saturday, August 24. 
Pigeons lie dead on the ground on August 24 from after what activists say is the use of chemical weapons by government forces in the Damascus suburb of Arbeen. 
Columns of smoke rise in Barzeh after heavy shelling on Friday, August 23. 
A young Free Syrian Army fighter is reflected in a mirror as he takes position in a house in Aleppo on Thursday, August 22. 
Rebels move around a building in Aleppo on August 22. 
Syrian rebels claim pro-government forces used chemical weapons to kill citizens outside Damascus on Wednesday, August 21. People inspect bodies in this photo released by the Syrian opposition Shaam News Network. 
People search the rubble of a bombed building in Aleppo, Syria, on Friday, August 16. 
Men bury the bodies of six members of the same family killed in a bombing in Raqqa on Saturday, August 10. 
Syrian Army soldiers patrol a devastated street in Homs on Wednesday, July 31. 
Free Syrian Army fighters move through a hole in a wall in Khan al-Assal on Monday, July 22, after seizing the town. 
A rebel fighter walks past swings in a deserted playground in Deir al-Zor, Syria, on Sunday, July 21. 
A rebel fighter speaks with a fellow fighter through a hole in a wall in Deir al-Zor on July 21. 
A Free Syrian Army fighter casts a shadow on a wall as he carries his weapon in a shelter in Deir al-Zor on Thursday, July 18. 
Yahya Sweed, 13, is comforted by his father as he lies on a bed in Kfar Nubul on Tuesday, July 16. The boy was injured by shrapnel, resulting in the amputation of his right leg. 
A rebel fighter naps in a trench about 300 feet from the Syrian government forces' positions along the highway connecting Idlib with Latakia on Monday, July 15. 
A rebel fighter uses a hole in the wall of a destroyed school to aim at Syrian government forces in the Izaa district of Aleppo on Sunday, July 14. 
A Free Syrian Army fighter uses a mirror to scope out snipers loyal to Syrian President Bashar al-Assad in Aleppo on Friday, July 12. 
A Free Syrian Army fighter stands over a boy who was injured during shelling in Al-Bara on Monday, July 8. 
Members of the Free Syrian Army fire a homemade rocket toward regime forces in Deir al-Zor on Sunday, June 16. 
Syrian rebels leave their position in the northwestern town of Maaret al-Numan on Thursday, June 13. The White House said that the Syrian government has crossed a "red line" with its use of chemical weapons and announced it would start arming the rebels. 
Forces loyal to Syrian President Bashar al-Assad are seen near Qusayr on Thursday, May 30. 
Syrian rebels take position in a house during clashes with regime forces in the old city of Aleppo on May 22. 
Syrian army soldiers take control of the village of Western Dumayna north of the rebel-held city of Qusayr on Monday, May 13. Syrian troops captured three villages in Homs province, allowing them to cut supply lines to rebels inside Qusayr town, a military officer told AFP. 
Rebel fighters fire at government forces in the northern Syrian city of Aleppo on Sunday, May 12. 
Searchers use a flashlight as they look for survivors among the rubble created by what activists say was a missile attack from the Syrian regime, in Raqqa province, Syria, on April 25. 
A Kurdish fighter from the "Popular Protection Units" (YPG) takes position inside a building in the majority-Kurdish Sheikh Maqsood area of Aleppo, on Apri. 21. 
People walk past destroyed houses in the northern Syrian town of Azaz on Sunday, April 21. 
Free Syrian Army fighters take positions prior to an offensive against government forces in the Khan al-Assal area, near Aleppo on Saturday, April 20. 
Men inspect damage at a house destroyed in an airstrike in Aleppo on April 15. 
Syrian and Kurdish rebel fighters walk in the Sheikh Maqsud district of Aleppo on April 14. 
A female rebel monitors the movement of Syrian government forces in Aleppo's Sheikh Maqsud neighborhood on Thursday, April 11. 
A rebel runs to avoid sniper fire from Syrian government forces in Aleppo on April 11. 
Syrian rebels observe the movement of Syrian government forces around Al-Kendi hospital in Aleppo on Wednesday, April 10. 
Rescue teams and security forces check out the scene of a deadly car bomb explosion in Damascus on April 8. 
The fighting has taken a toll on buildings in Aleppo's Saladin district, seen here on April 8. 
A Syrian rebel runs for cover in Deir ez-Zor on April 2. 
A rebel checks for snipers across the street toward the Citadel in Aleppo, Syria, on Saturday, March 30, in this photo taken by iReporter Lee Harper. 
A Free Syrian fighter mourns the death of a friend in Aleppo on March 30, in this photo taken by iReporter Lee Harper. 
A Syrian opposition fighter runs for cover from Syrian army snipers in Aleppo on Wednesday, March 27. 
A Syrian girl covers her face to protect herself from fumes as a street covered with uncollected garbage is fumigated in Aleppo on Sunday, March 24. 
A Syrian man and his family drive past damaged buildings in Maarat al-Numan, on Wednesday, March 20. 
Syrians carry the body of a Syrian army soldier during a funeral ceremony in Idlib province on Tuesday, March 19. 
Syrian rebels take position in Aleppo, the largest city in the country, on March 11. 
Syrian men search for their relatives amongst the bodies of civilians executed and dumped in the Quweiq River on March 11. 
A Free Syrian Army fighter looks back as smoke rises during fighting between rebel fighters and forces loyal to Syria's President Bashar al-Assad on the outskirts of Aleppo on Saturday, March 2. 
Residents read Shaam News newspapers published by the Free Syrian Army in Aleppo on March 2. 
A member of the Free Syrian Army reacts to the death of a comrade who was killed in fighting, at Bustan al Qasr cemetery in Aleppo on Friday, March 1. 
A rebel fighter throws a home-made grenade at Syrian government forces in Aleppo on February 16. 
A member of the Free Syrian Army stands with his weapon as he looks at a rainbow in Aleppo on February 16. 
A Syrian woman looks through a bus window in Aleppo on February 14. 
Free Syrian Army fighters walk through a dust-filled stairwell in Damascus on February 7. 
A Syrian rebel gestures at comrades from inside a broken armored personnel carrier in Al-Yaqubia on February 6. 
A rebel fighter throws a hand grenade inside a Syrian Army base in Damascus on February 3. 
People stand in the dust of a building destroyed in an airstrike in Aleppo, Syria on February 3. 
Free Syrian Army fighters run as they enter a Syrian Army base during heavy fighting in the Arabeen neighborhood of Damascus on February 3. 
An unexploded mortar shell fired by the Syrian Army sits lodged in the ground in Damascus on January 25. 
Fighters from Fateh al Sham unit of the Free Syrian Army fire on Syrian Army soldiers at a check point in Damascus on January 20. 
A Free Syrian Army fighter walks between buildings damaged during Syrian Air Force strikes in Damascus on January 19. 
A Syrian rebel fighter tries to locate a government jet fighter in Aleppo on January 18. 
Syrian rebels launch a missile near the Abu Baker brigade in Albab on January 16. 
A Syrian boy walks near rubbish next to tents at a refugee camp near the northern city of Azaz on the Syria-Turkey border, on January 8. 
Syrians look for survivors amid the rubble of a building targeted by a missile in Aleppo on January 7. 
A father reacts after hearing of a shelling by forces loyal to Syria's President Bashar al-Assad in Aleppo on January 3. 
A patient smokes a cigarette at Dar Al-Ajaza psychiatric hospital in Aleppo on December 18, 2012. The psychiatric ward, housing around 60 patients, has lacked the means to function properly since fighting broke out there in July. 
Syrians mourn a fallen rebel fighter at a rebel base in the al-Fardos area of Aleppo on December 8. 
Members of Liwa (Brigade) Salahadin, a Kurdish military unit fighting alongside rebel fighters, monitor the area in the besieged district of Karmel al-Jabl in Aleppo on December 6. 
A member of Liwa Salahadin aims at a regime fighter in the besieged district of Karmel al-Jabl in Aleppo on December 6. 
Two young boys sit underneath a washline in a refugee camp on the border between Syria and Turkey near Azaz on December 5. 
The bodies of three children, who were allegedly killed in a mortar shell attack that landed close to a bakery in Aleppo, on December 2, are laid out for identification by family members at a makeshift hospital at an undisclosed location of the city. 
Smoke rises in the Hanano and Bustan al-Basha districts in Aleppo on December 1 as fighting continues through the night. 
Damaged houses in Aleppo are seen after an airstrike on November 29. 
A Syrian rebel mourns the death of a comrade in Maraat al-Numan on November 20. 
Syrians protesters stand on Assad's portrait during an anti-regime demonstration in Aleppo on November 16. 
A Syrian rebel takes cover during fighting against Syrian government forces in Aleppo on November 15. 
Syrian opposition fighter Bazel Araj, 19, sleeps next to his pistol in Aleppo on November 11. 
A rebel fighter fires at a Syrian government position in Aleppo on November 6. 
A Syrian rebel leaps over debris left in the street while running across a "sniper alley" near the Salahudeen district in Aleppo on November 4. 
Rebels hold their position in the midst of a battle on November 3 in Aleppo. 
A man cries while being treated in a local hospital in a rebel-controlled area of Aleppo on October 31. 
A man is treated for wounds after a government jet attacked the Karm al-Aser neighborhood in eastern Aleppo on October 31. 
A Syrian rebel interrogates a handcuffed and blindfolded man suspected of being a pro-regime militiaman in Aleppo on October 26. 
Smoke rises from a fuel station following a mortar attack as Syrian women walk on a rainy day in the Arqub neighborhood of Aleppo on October 25. 
A Syrian rebel fires at an army position in the Karm al-Jabal district of Aleppo on October 22. 
A wounded Syrian boy sits on the back of a truck carrying victims and wounded people to a hospital following an attack by regime forces in Aleppo on October 21. 
A man lies on the ground after being shot by a sniper for a second time as he waits to be rescued by members of the Al-Baraa Bin Malek Battalion, part of the Free Syria Army's Al-Fatah brigade, in Aleppo on October 20. 
Syrian army soldiers run for cover during clashes with rebel fighters at Karam al-Jabal neighborhood of Aleppo on October 20. 
Smoke rises after a Syrian Air Force fighter jet fired missiles at the suburbs of the northern province of Idlib on October 16. 
A Syrian opposition fighter stands near a post in Aleppo on October 11. 
A Syrian man mourns the death of his father, who was killed during a government attack in Aleppo on October 10. 
A rebel fighter is carried by his friends and laid on a gurney to be treated for gunshot wounds sustained during heavy battles with government forces in Aleppo on October 1. 
Syrian rebels help a wounded comrade to an Aleppo hospital after he was injured in a Syrian army strike on September 18. 
Free Syria Army fighters are reflected in a mirror they use to see a Syrian Army post only 50 meters away in Aleppo on September 16. 
A Syrian man carrying grocery bags tries to dodge sniper fire as he runs through an alley near a checkpoint manned by the Free Syria Army in Aleppo on September 14. 
A woman walks past a destroyed building in Aleppo on September 13. 
Free Syrian Army fighters battle during street fighting against Syrian army soldiers in Aleppo on September 8. 
A Syrian man wounded by shelling sits on a chair outside a closed shop in Aleppo on September 4. 
A woman sits in her wheelchair next to her house, damaged by a Syrian air raid, near Homs on August 26. 
Members of the Free Syrian Army clash with Syrian army soliders in Aleppo's Saif al-Dawla district on August 22. 
A man mourns in front of a field hospital on August 21 in Aleppo. 
Wounded civilians wait in a field hospital after an air strike on August 21 in Aleppo. 
People pray during the funeral of a Free Syrian Army fighter, Amar Ali Amero, on August 21. 
A man cries near the graves of his two children killed during a recent Syrian airstrike in Azaz on August 20. 
A Syrian woman holds her dead baby as she screams upon seeing her husband's body being covered following an airstrike by regime forces on the town of Azaz on August 15. 
A Syrian rebel runs in a street of Selehattin during an attack on the municipal building on July 23. 
Syrian rebels hunt for snipers after attacking the municipality building in the city center of Selehattin on July 23. 
Members of the Free Syrian Army's Mugaweer (commandos) Brigade pay their respects in a cemetery on May 12 in Qusayr. 
Syrian rebels take position near Qusayr on May 10. 
A Free Syrian Army member takes cover in underground caves in Sarmin on April 9. 
Rebels prepare to engage government tanks that advanced into Saraquib on April 9. 
Men say prayers during a ceremony in Binnish on April 9. 
A young boy plays with a toy gun in Binnish on April 9. 
A Free Syrian Army rebel mounts his horse in the Al-Shatouria village near the Turkish border in northwestern Syria on March 16, a year after the uprising began. 
Syrian refugees walk across a field before crossing into Turkey on March 14. 
A rebel takes position in Al-Qsair on January 27. 
A protester in Homs throws a tear gas bomb back towards security forces, on December 27, 2011. 
A man stands under a giant Syrian flag outside the Umayyad Mosque in Damascus on December 24, 2011. 
A member of the Free Syrian Army looks out over a valley in the village of Ain al-Baida on December 15, 2011. 
Members of the Free Syrian Army stand in an valley near the village of Ain al-Baida, close to the Turkish border, on December 15, 2011. 
Displaced Syrian refugees walk through an orchard adjacent to Syria's northern border with Turkey on June 14, 2011, near Khirbet al-Jouz. 
A Syrian man holds up a portrait of President Bashar al-Assad during a rally to show support for the president in Damascus on April 30, 2011. 
Syrians rally to show their support for President Bashar al-Assad in Damascus on April 30, 2011. 
A screen grab from YouTube shows thick smoke rising above as Syrian anti-government protesters demonstrate in Moaret Al-Noman on April 29, 2011. 
A screen grab from YouTube shows Syrian anti-government protesters run for cover from tear gas fired by security forces in Damascus on April 29, 2011, during the "Day of Rage" demonstrations called by activists to put pressure on al-Assad. 
Syrians wave their national flag and hold portraits of al-Assad during a rally to show their support for their leader in Damascus on March 29, 2011. 
A woman sits by the hospital bed of a man allegedly injured when an armed group seized rooftops in Latakia on March 27, 2011, and opened fire at passers-by, citizens and security forces personnel according to official sources. 
Syrian protesters chant slogans in support of al-Assad during a rally in Damascus on March 25, 2011. 
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- Syria's Assad regime is accused of using chemical weapons on civilians
- Laurie Garrett: Sarin probably was deployed; those who die from it suffer terribly
- She says sarin was developed in WWII era as a potent form of destruction
- Garrett: It would be nightmare for Syrians to experience toxic gas in a litany of despair
Editor's note: Laurie Garrett is senior fellow for global health at the Council on Foreign Relations and a Pulitzer Prize-winning journalist.
(CNN) -- This week, the world is learning that on August 21, Syria's Assad regime attacked civilians living on the outskirts of Damascus, killing at least 355 of them, including many small children. According to Vice President Joe Biden, there is "no doubt" that chemical weapons were used by the regime -- and not, as the Assad government has claimed, by rebel forces.
The victims suffered terrible and painful deaths. Many experts are concluding that most likely a nerve agent such as sarin was deployed. Sarin is a type of organophosphate (OP), a class of chemicals used for making herbicides, insecticides and nerve gases.
The effects of sarin and other OPs on the human body are profound, shocking and can be long lasting. Some exposures have left the surviving victims paralyzed for weeks, with perhaps permanent liver malfunctions and lingering neurological dysfunctions.
OPs disintegrate in a matter of hours. But during their comparatively brief period of volatile danger, the deadly molecules can pass through human skin, nostrils, lungs and eyes to enter the bloodstream and then the brain. If enough of it gets inside the brain to saturate the nervous system, an agonizing death follows.
I first learned about sarin gas in 1978 when I was hired by the California Department of Food and Agriculture to assess the human health impacts of 33,000 pesticide formulations used by farmers and pest eradication companies. Obviously the state wasn't serious about this. Who hires a 26-year-old graduate student immunologist to, by herself, evaluate so many chemicals?
What I found was that among the tens of thousands of chemicals used by growers and pest eradicators around the world, the most potent and popular were, and still are, the organophosphates. They kill insects by blocking proper regulation of the key chemical used by nerve cells, acetylcholine. (OPs became popular for agricultural use after DDT and some other chemicals were banned because they persist almost indefinitely in the environment.)
But now and then, a farmworker might inhale the odorless, tasteless OP chemicals when unknowingly downwind of a large pesticide spraying, and the ghastly neurological symptoms and deaths would ensue.
To understand how and why such dangerous compounds had come into common use, I dug backwards in the scientific literature, landing on the 1938 invention of the first member of this chemical family, sarin, developed by German chemist Gerhard Schrader.
Though Schrader started down the sarin path in search of agricultural chemicals, he recognized its utility as a nerve gas and aided his military in its development and use during WWII. During the Cold War, the United States, United Kingdom and Soviet Union all developed deadlier forms of OPs, including VX gas.
In 1993, the U.N.'s Chemical Weapons Convention banned sarin, VX and other nerve gases. The CWC also targeted compounds used to make deadly gases, such as methylphosphonyl difluoride -- a harmless chemical until mixed with rubbing alcohol, creating sarin. The CWC was signed by 162 nations, including the U.S. and Soviet Union. But Syria has never signed it, and the regime of Bashar al-Assad has stockpiled ready-to-mix methylphosphonyl difluoride in vast quantities.
Biden: 'There is no doubt' about Syria 
Miller: Strike will not change crisis Three decades ago, I found it shocking to learn that so much OP pesticides used annually in the United States to control insects were, chemically, close siblings to those deployed for genocidal purposes.
But then it came back as a weapon of war.
On March 16, 1988, the Iraqi government of Saddam Hussein showered the Kurdish village of Halabja with multiple chemical agents, including sarin, killing several thousand civilians. This was the largest-scale chemical weapons attack in modern history.
Seven years later, the first terrorist use of sarin occurred in Tokyo, carried out by the strange religious cult Aum Shinrikyo. On March 20, 1995, the group released sarin in the city's subway system, killing 13 people and injuring more than 6000, with many requiring hospitalization.
More recently, an apparently corrupt principal in India fed children in her school cheap, OP-contaminated lunches, killing at least 25 youngsters. Witnesses described the children's hideous deaths as the pesticides caused their nervous systems to send signals to their muscles, leading to spasms and seizures. And then, in response, their lungs became paralyzed and the terrified children gasped and suffocated until they died.
In December, The New York Times and WIRED magazine reported that the Assad government was moving some of its chemical weapons in an apparent preparation for an attack. The deadly stockpile was stored in a safe form. A launchable shell is divided in half by a thin membrane.
On one side is rubbing alcohol, on the other, methylphosphonyl difluoride. Divided, the chemicals pose no hazard and can easily be transported and stored. But upon detonation, the membrane bursts, the chemicals mix, sarin gas is made and it showers upon those unfortunates below.
In March, sarin was used in Syria in a small attack. U.N. investigators have testimony that rebel forces may have used it. This month's attacks outside of Damascus, however, was clearly carried out by the Assad regime, according to the U.S and Britain.
A year ago on August 20, President Barack Obama made his now-famous "red line" remark, stating: "We have been very clear to the Assad regime, but also to other players on the ground, that a red line for us is we start seeing a whole bunch of chemical weapons moving around or being utilized. That would change my calculus. That would change my equation."
That was the diplomatic line in the sand for the U.S. In October of the same year, Ali Akbar Salehi, Iran's foreign minister at the time, addressed the Council on Foreign Relations in New York and drew his line. I asked him, "If the Syrian government makes use of its well-known stockpiles of either biological or chemical weapons, and the wind blows said weapons across your border, claiming Iranian lives, will this be considered a national security threat?"
"Certainly, that situation is a situation that will end everything," Salehi said. Iran is the key ally of the Assad regime. But what if powerful winds were to carry sarin or other chemical weapons from Syria to the Iranian border?
Salehi added, "that is the end of the validity, eligibility, legality, whatever you name it, of that government. Weapons of mass destruction, as we said, is against humanity. It's something that is not at all acceptable. And therefore, if your hypothesis, God forbid, ever materializes, I think nobody can justify it anymore, nobody can go along with anybody who has been involved in such act of -- I would say inhuman act."
The Assad regime is playing with regional fire.
While the possibility of a wind carrying sarin to far-away Iran might be ridiculous, the Lebanese border is merely 15 miles from Damascus and Jordan's is 70 miles away.
A "new normal" has descended over the Middle East since the 2011 Arab Spring, pushing ever more dangerous boundaries of instability and brutality, mass refugee exoduses, tough military crackdowns, suicide bombings, demolition of mosques and Coptic churches and spread of diseases.
It would be nightmarish in the extreme were use of chemical weapons -- deployment for purposes of mass asphyxiation -- to join the awful "new normal" litany of despair.
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The opinions expressed in this commentary are solely those of Laurie Garrett.
